Assay Detail
Binding
CHEMBL4398708
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine aortic smooth muscle PDE4 at 10 uM using cAMP as substrate incubated for 30 mins in presence of EGTA and [3H]cAMP by liquid scintillation counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.43 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441100 | — | — | 1 | 6.50 |
| CHEMBL4586506 | — | — | 1 | 5.36 |
| CHEMBL332898 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441100 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4586506 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL332898 | — | IC50 | = | 37000.0 | nM | 4.43 |