Assay Detail
Binding
CHEMBL4398996
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at TLR2 in mouse RAW264.7 cells assessed as PAM3CSK4-induced NO production measured after 24 hrs by Griess assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship study and biological evaluation of SAC-Garlic acid conjugates as novel anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.32 | 4.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4520213 | — | — | 1 | 4.65 |
| CHEMBL4476502 | — | — | 1 | 4.56 |
| CHEMBL4565255 | — | — | 1 | 4.54 |
| CHEMBL4550068 | — | — | 1 | 4.50 |
| CHEMBL4469404 | — | — | 1 | 4.49 |
| CHEMBL4519438 | — | — | 1 | 4.45 |
| CHEMBL4583040 | — | — | 1 | 4.43 |
| CHEMBL4548002 | — | — | 1 | 4.42 |
| CHEMBL4472039 | — | — | 1 | 4.41 |
| CHEMBL4443238 | — | — | 1 | 4.39 |
| CHEMBL4470035 | — | — | 1 | 4.38 |
| CHEMBL4471836 | — | — | 1 | 4.34 |
| CHEMBL4454839 | — | — | 1 | 4.31 |
| CHEMBL4558784 | — | — | 1 | 4.30 |
| CHEMBL4580219 | — | — | 1 | 4.30 |
| CHEMBL4451849 | — | — | 1 | 4.28 |
| CHEMBL4447150 | — | — | 1 | 4.28 |
| CHEMBL4553235 | — | — | 1 | 4.28 |
| CHEMBL4519867 | — | — | 1 | 4.27 |
| CHEMBL377172 | 3,4,5-TRIMETHOXYBENZOIC ACID | — | 1 | 4.27 |
| CHEMBL4440135 | — | — | 1 | 4.26 |
| CHEMBL4527499 | — | — | 1 | 4.26 |
| CHEMBL4441243 | — | — | 1 | 4.26 |
| CHEMBL4438711 | — | — | 1 | 4.24 |
| CHEMBL4471558 | — | — | 1 | 4.24 |
| CHEMBL4555372 | — | — | 1 | 4.23 |
| CHEMBL4436559 | — | — | 1 | 4.22 |
| CHEMBL288114 | GALLIC ACID | 2.0 | 1 | 4.16 |
| CHEMBL4443117 | — | — | 1 | 4.15 |
| CHEMBL4565283 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4520213 | — | IC50 | = | 22540.0 | nM | 4.65 |
| CHEMBL4476502 | — | IC50 | = | 27320.0 | nM | 4.56 |
| CHEMBL4565255 | — | IC50 | = | 28570.0 | nM | 4.54 |
| CHEMBL4550068 | — | IC50 | = | 31280.0 | nM | 4.50 |
| CHEMBL4469404 | — | IC50 | = | 32650.0 | nM | 4.49 |
| CHEMBL4519438 | — | IC50 | = | 35820.0 | nM | 4.45 |
| CHEMBL4583040 | — | IC50 | = | 37300.0 | nM | 4.43 |
| CHEMBL4548002 | — | IC50 | = | 38350.0 | nM | 4.42 |
| CHEMBL4472039 | — | IC50 | = | 39220.0 | nM | 4.41 |
| CHEMBL4443238 | — | IC50 | = | 40470.0 | nM | 4.39 |
| CHEMBL4470035 | — | IC50 | = | 41810.0 | nM | 4.38 |
| CHEMBL4471836 | — | IC50 | = | 45540.0 | nM | 4.34 |
| CHEMBL4454839 | — | IC50 | = | 49280.0 | nM | 4.31 |
| CHEMBL4558784 | — | IC50 | = | 50210.0 | nM | 4.30 |
| CHEMBL4580219 | — | IC50 | = | 50520.0 | nM | 4.30 |
| CHEMBL4447150 | — | IC50 | = | 52120.0 | nM | 4.28 |
| CHEMBL4451849 | — | IC50 | = | 52130.0 | nM | 4.28 |
| CHEMBL4553235 | — | IC50 | = | 53040.0 | nM | 4.28 |
| CHEMBL4519867 | — | IC50 | = | 53220.0 | nM | 4.27 |
| CHEMBL377172 | 3,4,5-TRIMETHOXYBENZOIC ACID | IC50 | = | 53800.0 | nM | 4.27 |
| CHEMBL4440135 | — | IC50 | = | 54910.0 | nM | 4.26 |
| CHEMBL4527499 | — | IC50 | = | 54760.0 | nM | 4.26 |
| CHEMBL4441243 | — | IC50 | = | 54370.0 | nM | 4.26 |
| CHEMBL4438711 | — | IC50 | = | 57750.0 | nM | 4.24 |
| CHEMBL4471558 | — | IC50 | = | 57750.0 | nM | 4.24 |
| CHEMBL4555372 | — | IC50 | = | 58470.0 | nM | 4.23 |
| CHEMBL4436559 | — | IC50 | = | 60670.0 | nM | 4.22 |
| CHEMBL288114 | GALLIC ACID | IC50 | = | 69250.0 | nM | 4.16 |
| CHEMBL4443117 | — | IC50 | = | 71460.0 | nM | 4.15 |
| CHEMBL4565283 | — | IC50 | = | 94370.0 | nM | 4.03 |
| CHEMBL4542434 | — | IC50 | = | 99550.0 | nM | 4.00 |
| CHEMBL441343 | PARABEN | IC50 | = | 118110.0 | nM | - |
| CHEMBL95308 | 3,5-DIHYDROXYBENZOIC ACID | IC50 | = | 117110.0 | nM | - |
| CHEMBL4472715 | — | IC50 | = | 116730.0 | nM | - |