Assay Detail
Binding
CHEMBL4399059
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]U-69593 from human recombinant KOR expressed in CHO cell membranes incubated for 2 hrs by liquid scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Endomorphin-2 analogs containing modified tyrosines: Biological and theoretical investigation of the influence on conformation and pharmacological profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.90 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4514319 | — | — | 1 | 7.43 |
| CHEMBL331325 | — | — | 1 | 6.28 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 5.95 |
| CHEMBL4475274 | — | — | 1 | 5.35 |
| CHEMBL4466953 | — | — | 1 | 5.33 |
| CHEMBL4527584 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4514319 | — | Ki | = | 37.3 | nM | 7.43 |
| CHEMBL331325 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL333357 | ENDOMORPHIN 2 | Ki | = | 1136.0 | nM | 5.95 |
| CHEMBL4475274 | — | Ki | = | 4478.0 | nM | 5.35 |
| CHEMBL4466953 | — | Ki | = | 4650.0 | nM | 5.33 |
| CHEMBL4527584 | — | Ki | = | 9150.0 | nM | 5.04 |