Assay Detail
Functional
CHEMBL4399243
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Cytotoxicity against human MCF7 cells expressing VEGFR2 and wild type BRAF measured after 48 hrs by sulforhodamine B assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel potent substituted 4-amino-2-thiopyrimidines as dual VEGFR-2 and BRAF kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.46 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.36 |
| CHEMBL4573547 | — | — | 1 | 4.88 |
| CHEMBL4448435 | — | — | 1 | 4.78 |
| CHEMBL4561629 | — | — | 1 | 4.76 |
| CHEMBL4558790 | — | — | 1 | 4.76 |
| CHEMBL4471650 | — | — | 1 | 4.71 |
| CHEMBL4453308 | — | — | 1 | 4.70 |
| CHEMBL4549103 | — | — | 1 | 4.64 |
| CHEMBL4474922 | — | — | 1 | 4.61 |
| CHEMBL4449189 | — | — | 1 | 4.57 |
| CHEMBL4557976 | — | — | 1 | 4.55 |
| CHEMBL4566054 | — | — | 1 | 4.49 |
| CHEMBL4574832 | — | — | 1 | 4.43 |
| CHEMBL4434973 | — | — | 1 | 4.42 |
| CHEMBL4438418 | — | — | 1 | 4.31 |
| CHEMBL4450118 | — | — | 1 | 4.27 |
| CHEMBL4539297 | — | — | 1 | 4.27 |
| CHEMBL4465126 | — | — | 1 | 4.26 |
| CHEMBL4590013 | — | — | 1 | 4.18 |
| CHEMBL4547466 | — | — | 1 | 4.17 |
| CHEMBL4474945 | — | — | 1 | 4.17 |
| CHEMBL4469216 | — | — | 1 | 4.16 |
| CHEMBL4470636 | — | — | 1 | 4.16 |
| CHEMBL4570955 | — | — | 1 | 4.13 |
| CHEMBL4441990 | — | — | 1 | 4.09 |
| CHEMBL4467107 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL4573547 | — | IC50 | = | 13020.0 | nM | 4.88 |
| CHEMBL4448435 | — | IC50 | = | 16540.0 | nM | 4.78 |
| CHEMBL4561629 | — | IC50 | = | 17180.0 | nM | 4.76 |
| CHEMBL4558790 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL4471650 | — | IC50 | = | 19610.0 | nM | 4.71 |
| CHEMBL4453308 | — | IC50 | = | 19980.0 | nM | 4.70 |
| CHEMBL4549103 | — | IC50 | = | 23010.0 | nM | 4.64 |
| CHEMBL4474922 | — | IC50 | = | 24370.0 | nM | 4.61 |
| CHEMBL4449189 | — | IC50 | = | 26880.0 | nM | 4.57 |
| CHEMBL4557976 | — | IC50 | = | 28210.0 | nM | 4.55 |
| CHEMBL4566054 | — | IC50 | = | 32110.0 | nM | 4.49 |
| CHEMBL4574832 | — | IC50 | = | 37160.0 | nM | 4.43 |
| CHEMBL4434973 | — | IC50 | = | 37800.0 | nM | 4.42 |
| CHEMBL4438418 | — | IC50 | = | 49040.0 | nM | 4.31 |
| CHEMBL4450118 | — | IC50 | = | 53240.0 | nM | 4.27 |
| CHEMBL4539297 | — | IC50 | = | 53630.0 | nM | 4.27 |
| CHEMBL4465126 | — | IC50 | = | 55190.0 | nM | 4.26 |
| CHEMBL4590013 | — | IC50 | = | 66140.0 | nM | 4.18 |
| CHEMBL4547466 | — | IC50 | = | 67550.0 | nM | 4.17 |
| CHEMBL4474945 | — | IC50 | = | 67070.0 | nM | 4.17 |
| CHEMBL4469216 | — | IC50 | = | 68510.0 | nM | 4.16 |
| CHEMBL4470636 | — | IC50 | = | 69050.0 | nM | 4.16 |
| CHEMBL4570955 | — | IC50 | = | 73270.0 | nM | 4.13 |
| CHEMBL4441990 | — | IC50 | = | 81250.0 | nM | 4.09 |
| CHEMBL4467107 | — | IC50 | = | 80310.0 | nM | 4.09 |