Assay Detail
Binding
CHEMBL4399583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.84 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4590477 | — | — | 1 | 6.16 |
| CHEMBL4589844 | — | — | 1 | 5.52 |
| CHEMBL4457150 | — | — | 1 | - |
| CHEMBL4587816 | — | — | 1 | - |
| CHEMBL4461649 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4590477 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4589844 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4457150 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4587816 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4461649 | — | IC50 | > | 10000.0 | nM | - |