Assay Detail
Binding
CHEMBL4399812
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3K gamma (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins in presence of ATP by Kinase-Glo Plus reagent-based luminescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of 4-(piperid-3-yl)amino substituted 6-pyridylquinazolines as potent PI3Kδ inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.31 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4468088 | — | — | 1 | 8.70 |
| CHEMBL4457318 | — | — | 1 | 7.71 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 6.84 |
| CHEMBL4473306 | — | — | 1 | 6.68 |
| CHEMBL4476303 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4468088 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4457318 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 145.3 | nM | 6.84 |
| CHEMBL4473306 | — | IC50 | = | 210.7 | nM | 6.68 |
| CHEMBL4476303 | — | IC50 | = | 250.4 | nM | 6.60 |