Assay Detail
Binding
CHEMBL4400163
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Binding affinity to human C5a assessed as dissociation constant after 1 hr by circular dichroism analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A rational search for discovering potential neutraligands of human complement fragment 5a (<sup>h</sup>C5a).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.21 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1316 | CARPROFEN | 4.0 | 1 | 6.24 |
| CHEMBL15770 | SULINDAC | 4.0 | 1 | 6.24 |
| CHEMBL1071 | OXAPROZIN | 4.0 | 1 | 6.19 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1316 | CARPROFEN | Kd | = | 580.0 | nM | 6.24 |
| CHEMBL15770 | SULINDAC | Kd | = | 570.0 | nM | 6.24 |
| CHEMBL1071 | OXAPROZIN | Kd | = | 640.0 | nM | 6.19 |
| CHEMBL81 | RALOXIFENE | Kd | = | 710.0 | nM | 6.15 |