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Assay Detail

CHEMBL4400282

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Binding
Inhibition of recombinant human liver soluble epoxide hydrolase expressed in baculovirus infected Sf21 cells using NEPC as substrate by fluorescence based assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Sf21
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Bifunctional epoxide hydrolase 2 (CHEMBL2409)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors.
Codony S, Valverde E, Leiva R, Brea J, Isabel Loza M, Morisseau C, Hammock BD, Vázquez S.
Bioorg Med Chem (2019) 27 : 115078 -115078
PubMed 31488357 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 8.65 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1818385 1 9.40
CHEMBL1818384 1 9.40
CHEMBL4454212 1 9.40
CHEMBL4448782 1 9.30
CHEMBL242459 1 9.30
CHEMBL4535555 1 9.30
CHEMBL4448746 1 8.49
CHEMBL4458692 1 8.48
CHEMBL4530604 1 8.47
CHEMBL4516638 1 8.19
CHEMBL4467051 1 8.14
CHEMBL4463408 1 8.10
CHEMBL436774 AR9281 2.0 1 8.10
CHEMBL4465856 1 8.07
CHEMBL4447946 1 7.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1818385 IC50 = 0.4 nM 9.40
CHEMBL1818384 IC50 = 0.4 nM 9.40
CHEMBL4454212 IC50 = 0.4 nM 9.40
CHEMBL4448782 IC50 = 0.5 nM 9.30
CHEMBL242459 IC50 = 0.5 nM 9.30
CHEMBL4535555 IC50 = 0.5 nM 9.30
CHEMBL4448746 IC50 = 3.2 nM 8.49
CHEMBL4458692 IC50 = 3.3 nM 8.48
CHEMBL4530604 IC50 = 3.4 nM 8.47
CHEMBL4516638 IC50 = 6.5 nM 8.19
CHEMBL4467051 IC50 = 7.2 nM 8.14
CHEMBL4463408 IC50 = 8.0 nM 8.10
CHEMBL436774 AR9281 IC50 = 8.0 nM 8.10
CHEMBL4465856 IC50 = 8.6 nM 8.07
CHEMBL4447946 IC50 = 21.7 nM 7.66