Assay Detail
Functional
CHEMBL4400319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An exploration of solvent-front region high affinity moiety leading to novel potent ALK & ROS1 dual inhibitors with mutant-combating effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.47 | 5.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 5.99 |
| CHEMBL4448400 | — | — | 1 | 5.90 |
| CHEMBL4471142 | — | — | 1 | 5.82 |
| CHEMBL4471628 | — | — | 1 | 5.65 |
| CHEMBL4462528 | — | — | 1 | 5.53 |
| CHEMBL4516260 | — | — | 1 | 5.51 |
| CHEMBL4436697 | — | — | 1 | 5.49 |
| CHEMBL4566617 | — | — | 1 | 5.44 |
| CHEMBL4468370 | — | — | 1 | 5.39 |
| CHEMBL4462608 | — | — | 1 | 5.38 |
| CHEMBL4569983 | — | — | 1 | 5.33 |
| CHEMBL4540084 | — | — | 1 | 5.26 |
| CHEMBL4461807 | — | — | 1 | 5.25 |
| CHEMBL4536955 | — | — | 1 | 5.22 |
| CHEMBL4452164 | — | — | 1 | 5.18 |
| CHEMBL4449742 | — | — | 1 | 5.17 |
| CHEMBL4592666 | — | — | 1 | - |
| CHEMBL4446022 | — | — | 1 | - |
| CHEMBL4467298 | — | — | 1 | - |
| CHEMBL4562805 | — | — | 1 | - |
| CHEMBL4572661 | — | — | 1 | - |
| CHEMBL4460117 | — | — | 1 | - |
| CHEMBL4580622 | — | — | 1 | - |
| CHEMBL4531143 | — | — | 1 | - |
| CHEMBL4483504 | — | — | 1 | - |
| CHEMBL4519461 | — | — | 1 | - |
| CHEMBL4473400 | — | — | 1 | - |
| CHEMBL4457180 | — | — | 1 | - |
| CHEMBL4459181 | — | — | 1 | - |
| CHEMBL4573678 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2403108 | CERITINIB | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4448400 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4471142 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4471628 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL4462528 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL4516260 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL4436697 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL4566617 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL4468370 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL4462608 | — | IC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL4569983 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL4540084 | — | IC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL4461807 | — | IC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL4536955 | — | IC50 | = | 6070.0 | nM | 5.22 |
| CHEMBL4452164 | — | IC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL4449742 | — | IC50 | = | 6770.0 | nM | 5.17 |
| CHEMBL4434682 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4592055 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4454973 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4444127 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4515407 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4546844 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4573678 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4459181 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4457180 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4473400 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4519461 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4483504 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4531143 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4580622 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4460117 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4572661 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4562805 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4467298 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4446022 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4592666 | — | IC50 | > | 10000.0 | nM | - |