Assay Detail
Functional
CHEMBL4400341
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Antiviral activity against Influenza A virus (H1N1) harboring PR8-GLuc infected in human A549 cells assessed as reduction in virus-induced cytopathic effect treated post viral infection for 1 hr by luciferase reporter gene assay
34
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | H1N1 subtype |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 7.42 | 8.40 |
| EC90 | 17 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318007 | PIMODIVIR | 3.0 | 2 | 8.40 |
| CHEMBL4463009 | — | — | 2 | 8.19 |
| CHEMBL4483552 | — | — | 2 | 8.15 |
| CHEMBL4514267 | — | — | 2 | 7.92 |
| CHEMBL4579156 | — | — | 2 | 7.80 |
| CHEMBL4452071 | — | — | 2 | 7.77 |
| CHEMBL4528691 | — | — | 2 | 7.57 |
| CHEMBL4449092 | — | — | 2 | 7.54 |
| CHEMBL4472799 | — | — | 2 | 7.38 |
| CHEMBL4528494 | — | — | 2 | 7.30 |
| CHEMBL4474039 | — | — | 2 | 7.30 |
| CHEMBL4439048 | — | — | 2 | 6.40 |
| CHEMBL4440485 | — | — | 2 | 6.17 |
| CHEMBL4550840 | — | — | 2 | 6.02 |
| CHEMBL4452851 | — | — | 2 | - |
| CHEMBL4446344 | — | — | 2 | - |
| CHEMBL4476304 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318007 | PIMODIVIR | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4463009 | — | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4483552 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4514267 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4579156 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4452071 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4528691 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4449092 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4472799 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4474039 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4528494 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4439048 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4440485 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4550840 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4452851 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4446344 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4476304 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL3318007 | PIMODIVIR | EC90 | = | 0.027 | uM | - |
| CHEMBL4483552 | — | EC90 | = | 0.027 | uM | - |
| CHEMBL4474039 | — | EC90 | = | 0.21 | uM | - |
| CHEMBL4528494 | — | EC90 | = | 0.28 | uM | - |
| CHEMBL4550840 | — | EC90 | = | 5.1 | uM | - |
| CHEMBL4463009 | — | EC90 | = | 0.047 | uM | - |
| CHEMBL4452071 | — | EC90 | = | 0.1 | uM | - |
| CHEMBL4472799 | — | EC90 | = | 0.14 | uM | - |
| CHEMBL4514267 | — | EC90 | = | 0.036 | uM | - |
| CHEMBL4440485 | — | EC90 | = | 2.5 | uM | - |
| CHEMBL4476304 | — | EC90 | - | — | - | |
| CHEMBL4446344 | — | EC90 | - | — | - | |
| CHEMBL4452851 | — | EC90 | - | — | - | |
| CHEMBL4439048 | — | EC90 | = | 2.0 | uM | - |
| CHEMBL4449092 | — | EC90 | = | 0.082 | uM | - |
| CHEMBL4579156 | — | EC90 | = | 0.044 | uM | - |
| CHEMBL4528691 | — | EC90 | = | 0.14 | uM | - |