Assay Detail
ADMET
CHEMBL4400469
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Inhibition of human neutrophil elastase using MeOSuc-AAPV-AMC as substrate incubated for 40 mins by FLINT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.11 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4460168 | — | — | 1 | 6.10 |
| CHEMBL4461533 | — | — | 1 | 5.90 |
| CHEMBL4543039 | — | — | 1 | 5.80 |
| CHEMBL4579813 | — | — | 1 | 5.30 |
| CHEMBL4535907 | — | — | 1 | 5.20 |
| CHEMBL4436048 | — | — | 1 | 4.90 |
| CHEMBL4517343 | — | — | 1 | 4.80 |
| CHEMBL4536142 | — | — | 1 | 4.60 |
| CHEMBL4464120 | — | — | 1 | 4.50 |
| CHEMBL4448315 | — | — | 1 | 4.00 |
| CHEMBL4447752 | — | — | 1 | - |
| CHEMBL4473069 | — | — | 1 | - |
| CHEMBL4547455 | — | — | 1 | - |
| CHEMBL4558285 | — | — | 1 | - |
| CHEMBL4465265 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4460168 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4461533 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4543039 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4579813 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL4535907 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4436048 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL4517343 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL4536142 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL4464120 | — | IC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL4448315 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL4447752 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4473069 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4547455 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4558285 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4465265 | — | IC50 | > | 100000.0 | nM | - |