Assay Detail
Binding
CHEMBL4400501
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Inhibition of human FGFR3 V555M mutant using FL-peptide substrate measured after 45 mins in presence of ATP by mobility shift assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Second-Generation FGFR Inhibitors for the Treatment of Cancers Harboring Mutated FGFRs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.03 | 9.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4577380 | — | — | 1 | 9.67 |
| CHEMBL4568760 | — | — | 1 | 9.58 |
| CHEMBL4461304 | — | — | 1 | 9.54 |
| CHEMBL4529789 | — | — | 1 | 9.39 |
| CHEMBL4443370 | — | — | 1 | 9.39 |
| CHEMBL4447174 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4577380 | — | IC50 | = | 0.212 | nM | 9.67 |
| CHEMBL4568760 | — | IC50 | = | 0.2645 | nM | 9.58 |
| CHEMBL4461304 | — | IC50 | = | 0.2885 | nM | 9.54 |
| CHEMBL4529789 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL4443370 | — | IC50 | = | 0.4081 | nM | 9.39 |
| CHEMBL4447174 | — | IC50 | = | 254.3 | nM | 6.59 |