Assay Detail
Binding
CHEMBL4400503
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild-type FGFR3 (unknown origin) expressed in mouse NIH/3T3 cells overexpressing wild type FGFR3-TACC3 assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Second-Generation FGFR Inhibitors for the Treatment of Cancers Harboring Mutated FGFRs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.46 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4529789 | — | — | 1 | 8.23 |
| CHEMBL4577380 | — | — | 1 | 8.23 |
| CHEMBL4443370 | — | — | 1 | 7.95 |
| CHEMBL4568760 | — | — | 1 | 7.76 |
| CHEMBL4461304 | — | — | 1 | 7.57 |
| CHEMBL4447174 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4529789 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL4577380 | — | IC50 | = | 5.896 | nM | 8.23 |
| CHEMBL4443370 | — | IC50 | = | 11.14 | nM | 7.95 |
| CHEMBL4568760 | — | IC50 | = | 17.41 | nM | 7.76 |
| CHEMBL4461304 | — | IC50 | = | 26.66 | nM | 7.57 |
| CHEMBL4447174 | — | IC50 | = | 10000.0 | nM | 5.00 |