Assay Detail
ADMET
CHEMBL4400811
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Cytotoxicity against human IMR90 cells assessed as reduction in cell viability after 48 hrs by Resazurin dye-based assay
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | IMR-90 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Aurone derivatives as promising antibacterial agents against resistant Gram-positive pathogens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 5 | - | - |
| IC50 | 5 | 4.31 | 4.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1814449 | — | — | 2 | 4.51 |
| CHEMBL1814448 | — | — | 2 | 4.10 |
| CHEMBL382905 | — | — | 2 | - |
| CHEMBL1814451 | — | — | 2 | - |
| CHEMBL2288227 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1814449 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL1814448 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL382905 | — | Activity | - | — | - | |
| CHEMBL382905 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL1814451 | — | Activity | - | — | - | |
| CHEMBL1814451 | — | IC50 | = | 620000.0 | nM | - |
| CHEMBL1814448 | — | Activity | - | — | - | |
| CHEMBL1814449 | — | Activity | - | — | - | |
| CHEMBL2288227 | — | Activity | - | — | - | |
| CHEMBL2288227 | — | IC50 | = | 340000.0 | nM | - |