Assay Detail
Functional
CHEMBL4401557
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Cytotoxicity against human NCI-H526 cells assessed as reduction in cell viability after 72 hrs by presto-blue assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H526 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of 1,2-Bis(hydroxymethyl)pyrrolo[2,1- a]phthalazine Hybrids as Potent Anticancer Agents that Inhibit Angiogenesis and Induce DNA Interstrand Cross-links.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.59 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447855 | — | — | 1 | 7.85 |
| CHEMBL4472721 | — | — | 1 | 7.00 |
| CHEMBL4514888 | — | — | 1 | 6.68 |
| CHEMBL4468286 | — | — | 1 | 6.52 |
| CHEMBL4520682 | — | — | 1 | 6.24 |
| CHEMBL4457799 | — | — | 1 | 6.12 |
| CHEMBL4436996 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447855 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4472721 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4514888 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4468286 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4520682 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4457799 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4436996 | — | IC50 | = | 1950.0 | nM | 5.71 |