Assay Detail
Functional
CHEMBL4401970
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Antiproliferative activity against human COLO201 cells after 24 hrs by WST-1 assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 201 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of trichothecenes against COLO201 cells and Cochliobolus miyabeanus: The role of 12-epoxide and macrocyclic moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.26 | 4.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4451123 | — | — | 1 | 4.38 |
| CHEMBL4455454 | — | — | 1 | 4.34 |
| CHEMBL4459598 | — | — | 1 | 4.33 |
| CHEMBL4441920 | — | — | 1 | 4.30 |
| CHEMBL4457991 | — | — | 1 | 4.29 |
| CHEMBL4579772 | — | — | 1 | 4.29 |
| CHEMBL4474411 | — | — | 1 | 4.09 |
| CHEMBL513300 | DEOXYNIVALENOL | — | 1 | 4.07 |
| CHEMBL4463552 | — | — | 1 | - |
| CHEMBL4442670 | — | — | 1 | - |
| CHEMBL4594005 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4451123 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL4455454 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL4459598 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL4441920 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4457991 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL4579772 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL4474411 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL513300 | DEOXYNIVALENOL | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL4463552 | — | IC50 | = | 123000.0 | nM | - |
| CHEMBL4442670 | — | IC50 | = | 420000.0 | nM | - |
| CHEMBL4594005 | — | IC50 | > | 700000.0 | nM | - |