Assay Detail
Binding
CHEMBL4401978
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant G4A cPLA2 using arachidonyl-1-14C PAPC , PAPC and PIP2 incubated for 30 mins by HPLC-MS analysis based radioactivity-based group specific mixed micelle assay
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
β-Lactones: A Novel Class of Ca<sup>2+</sup>-Independent Phospholipase A<sub>2</sub> (Group VIA iPLA<sub>2</sub>) Inhibitors with the Ability To Inhibit β-Cell Apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| XI50 | 3 | - | - |
| IC50 | 1 | 4.66 | 4.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4476476 | — | — | 2 | 4.66 |
| CHEMBL4440212 | — | — | 1 | - |
| CHEMBL4462080 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4476476 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4440212 | — | XI50 | = | 0.0019 | mole fraction | - |
| CHEMBL4462080 | — | XI50 | = | 4e-05 | mole fraction | - |
| CHEMBL4476476 | — | XI50 | = | 0.042 | mole fraction | - |