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Assay Detail

CHEMBL4402109

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of His-tagged p97 (unknown origin) in presence of ATP and PNP by UV-transparent microplate assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Transitional endoplasmic reticulum ATPase (CHEMBL1075145)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of Irreversible p97 Inhibitors.
Ding R, Zhang T, Wilson DJ, Xie J, Williams J, Xu Y, Ye Y, Chen L.
J Med Chem (2019) 62 : 2814 -2829
PubMed 30830772 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 7.52 7.73

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4555451 1 7.73
CHEMBL4553677 1 7.68
CHEMBL4535337 1 7.62
CHEMBL4441270 1 7.61
CHEMBL3747513 CB-5083 1.0 1 7.58
CHEMBL4453010 1 7.58
CHEMBL4551165 1 7.57
CHEMBL4543206 1 7.55
CHEMBL3747448 1 7.54
CHEMBL4463657 1 7.51
CHEMBL4580172 1 7.50
CHEMBL4460205 1 7.49
CHEMBL4459139 1 7.48
CHEMBL4438398 1 7.48
CHEMBL4463689 1 7.43
CHEMBL4558932 1 7.42
CHEMBL4446356 1 7.39
CHEMBL4535642 1 7.37
CHEMBL4456523 1 7.37

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4555451 Ki = 18.6 nM 7.73
CHEMBL4553677 Ki = 20.8 nM 7.68
CHEMBL4535337 Ki = 24.1 nM 7.62
CHEMBL4441270 Ki = 24.5 nM 7.61
CHEMBL3747513 CB-5083 Ki = 26.1 nM 7.58
CHEMBL4453010 Ki = 26.6 nM 7.58
CHEMBL4551165 Ki = 26.9 nM 7.57
CHEMBL4543206 Ki = 28.1 nM 7.55
CHEMBL3747448 Ki = 28.6 nM 7.54
CHEMBL4463657 Ki = 30.6 nM 7.51
CHEMBL4580172 Ki = 31.4 nM 7.50
CHEMBL4460205 Ki = 32.3 nM 7.49
CHEMBL4459139 Ki = 33.2 nM 7.48
CHEMBL4438398 Ki = 32.8 nM 7.48
CHEMBL4463689 Ki = 37.3 nM 7.43
CHEMBL4558932 Ki = 37.9 nM 7.42
CHEMBL4446356 Ki = 40.8 nM 7.39
CHEMBL4535642 Ki = 42.4 nM 7.37
CHEMBL4456523 Ki = 43.0 nM 7.37