Assay Detail
Binding
CHEMBL4402143
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Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of new ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as carbonic anhydrase I, II, IX and XII inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.82 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL4547531 | — | — | 1 | 7.52 |
| CHEMBL4448979 | — | — | 1 | 7.41 |
| CHEMBL4556985 | — | — | 1 | 7.38 |
| CHEMBL4587801 | — | — | 1 | 7.35 |
| CHEMBL4461238 | — | — | 1 | 7.11 |
| CHEMBL4539483 | — | — | 1 | 7.08 |
| CHEMBL4574353 | — | — | 1 | 7.03 |
| CHEMBL4451848 | — | — | 1 | 7.01 |
| CHEMBL4552490 | — | — | 1 | 6.71 |
| CHEMBL4452439 | — | — | 1 | 6.66 |
| CHEMBL4552193 | — | — | 1 | 6.60 |
| CHEMBL4568027 | — | — | 1 | 6.57 |
| CHEMBL4458581 | — | — | 1 | 6.38 |
| CHEMBL4557185 | — | — | 1 | 6.30 |
| CHEMBL4537582 | — | — | 1 | 6.13 |
| CHEMBL4462536 | — | — | 1 | 6.09 |
| CHEMBL4444999 | — | — | 1 | 6.08 |
| CHEMBL4456216 | — | — | 1 | 6.08 |
| CHEMBL4447240 | — | — | 1 | 6.03 |
| CHEMBL4467853 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1615281 | SLC-0111 | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL4547531 | — | Ki | = | 30.1 | nM | 7.52 |
| CHEMBL4448979 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL4556985 | — | Ki | = | 41.9 | nM | 7.38 |
| CHEMBL4587801 | — | Ki | = | 44.4 | nM | 7.35 |
| CHEMBL4461238 | — | Ki | = | 76.9 | nM | 7.11 |
| CHEMBL4539483 | — | Ki | = | 83.3 | nM | 7.08 |
| CHEMBL4574353 | — | Ki | = | 93.8 | nM | 7.03 |
| CHEMBL4451848 | — | Ki | = | 97.6 | nM | 7.01 |
| CHEMBL4552490 | — | Ki | = | 196.8 | nM | 6.71 |
| CHEMBL4452439 | — | Ki | = | 219.3 | nM | 6.66 |
| CHEMBL4552193 | — | Ki | = | 253.2 | nM | 6.60 |
| CHEMBL4568027 | — | Ki | = | 270.2 | nM | 6.57 |
| CHEMBL4458581 | — | Ki | = | 415.3 | nM | 6.38 |
| CHEMBL4557185 | — | Ki | = | 496.8 | nM | 6.30 |
| CHEMBL4537582 | — | Ki | = | 744.0 | nM | 6.13 |
| CHEMBL4462536 | — | Ki | = | 803.6 | nM | 6.09 |
| CHEMBL4444999 | — | Ki | = | 827.8 | nM | 6.08 |
| CHEMBL4456216 | — | Ki | = | 827.1 | nM | 6.08 |
| CHEMBL4447240 | — | Ki | = | 940.3 | nM | 6.03 |
| CHEMBL4467853 | — | Ki | = | 939.1 | nM | 6.03 |