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Assay Detail

CHEMBL4402389

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antibacterial activity against Campylobacter jejuni ATCC 33560 AS-83-79 measured after 16.4 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Campylobacter jejuni subsp. jejuni
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis.
Joshi S, Fedoseyenko D, Mahanta N, Ducati RG, Feng M, Schramm VL, Begley TP.
ACS Med Chem Lett (2019) 10 : 363 -366
PubMed 30891141 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 4 5.13 5.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1231347 1 5.85
CHEMBL1254452 GENTAMICIN C2 1 5.72
CHEMBL4461488 1 4.87
CHEMBL4534412 1 4.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1231347 IC50 = 1400.0 nM 5.85
CHEMBL1254452 GENTAMICIN C2 IC50 = 1900.0 nM 5.72
CHEMBL4461488 IC50 = 13600.0 nM 4.87
CHEMBL4534412 IC50 = 83300.0 nM 4.08