Assay Detail
Binding
CHEMBL4402615
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Mixed type inhibition of monophenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-Tyrosine substrate by UV-Vis spectrophotometry based Dixon plot analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.69 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9509 | SILIBININ | 3.0 | 1 | 6.16 |
| CHEMBL592676 | ISOSILYBIN A | — | 1 | 5.96 |
| CHEMBL2397733 | SILIDIANIN | 2.0 | 1 | 5.77 |
| CHEMBL130493 | SILICRISTIN A | — | 1 | 5.68 |
| CHEMBL589325 | SILICRISTIN B | — | 1 | 5.55 |
| CHEMBL3542340 | ISOSILYBIN B | — | 1 | 5.38 |
| CHEMBL4076992 | — | — | 1 | 5.33 |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9509 | SILIBININ | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL592676 | ISOSILYBIN A | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL2397733 | SILIDIANIN | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL130493 | SILICRISTIN A | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL589325 | SILICRISTIN B | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL3542340 | ISOSILYBIN B | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL4076992 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL287556 | KOJIC ACID | Ki | - | — | - |