Assay Detail
Binding
CHEMBL4402617
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of monophenolase activity of mushroom tyrosinase assessed as inhibition constant for free enzyme-inhibitor complex by measuring reduction in dopachrome formation using L-Tyrosine substrate by UV-Vis spectrophotometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.68 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9509 | SILIBININ | 3.0 | 1 | 6.16 |
| CHEMBL592676 | ISOSILYBIN A | — | 1 | 5.96 |
| CHEMBL2397733 | SILIDIANIN | 2.0 | 1 | 5.68 |
| CHEMBL130493 | SILICRISTIN A | — | 1 | 5.68 |
| CHEMBL589325 | SILICRISTIN B | — | 1 | 5.55 |
| CHEMBL3542340 | ISOSILYBIN B | — | 1 | 5.37 |
| CHEMBL4076992 | — | — | 1 | 5.34 |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
| CHEMBL66 | (+)-TAXIFOLIN | — | 1 | - |
| CHEMBL9323 | DIHYDROKAEMPFEROL | — | 1 | - |
| CHEMBL9353 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9509 | SILIBININ | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL592676 | ISOSILYBIN A | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL2397733 | SILIDIANIN | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL130493 | SILICRISTIN A | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL589325 | SILICRISTIN B | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL3542340 | ISOSILYBIN B | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL4076992 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL287556 | KOJIC ACID | Ki | - | — | - | |
| CHEMBL66 | (+)-TAXIFOLIN | Ki | - | — | - | |
| CHEMBL9323 | DIHYDROKAEMPFEROL | Ki | - | — | - | |
| CHEMBL9353 | — | Ki | - | — | - |