Assay Detail
Binding
CHEMBL4402619
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of diphenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-DOPA substrate by UV-Vis spectrophotometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.61 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9509 | SILIBININ | 3.0 | 1 | 4.92 |
| CHEMBL2397733 | SILIDIANIN | 2.0 | 1 | 4.78 |
| CHEMBL592676 | ISOSILYBIN A | — | 1 | 4.78 |
| CHEMBL3542340 | ISOSILYBIN B | — | 1 | 4.70 |
| CHEMBL66 | (+)-TAXIFOLIN | — | 1 | 4.57 |
| CHEMBL130493 | SILICRISTIN A | — | 1 | 4.54 |
| CHEMBL4076992 | — | — | 1 | 4.45 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.43 |
| CHEMBL589325 | SILICRISTIN B | — | 1 | 4.35 |
| CHEMBL9323 | DIHYDROKAEMPFEROL | — | 1 | - |
| CHEMBL9353 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9509 | SILIBININ | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL2397733 | SILIDIANIN | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL592676 | ISOSILYBIN A | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL3542340 | ISOSILYBIN B | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL66 | (+)-TAXIFOLIN | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL130493 | SILICRISTIN A | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL4076992 | — | IC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL589325 | SILICRISTIN B | IC50 | = | 44900.0 | nM | 4.35 |
| CHEMBL9323 | DIHYDROKAEMPFEROL | IC50 | > | 200000.0 | nM | - |
| CHEMBL9353 | — | IC50 | = | 150000.0 | nM | - |