Assay Detail
Binding
CHEMBL4402908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human 5-LOX expressed in baculovirus-infected insect cells preincubated for 10 mins followed by Arachidonic acid and ATP addition and measured after 20 mins by H2DCFD dye based fluorescence method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-Lipoxygenase as a drug target: A review on trends in inhibitors structural design, SAR and mechanism based approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.64 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4463974 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4463974 | — | IC50 | = | 229.0 | nM | 6.64 |