Assay Detail

CHEMBL4403190

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of HIV-2 ROD9 integrase Q148H mutant

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Human immunodeficiency virus 2
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Synthetic routes and structure-activity relationships (SAR) of anti-HIV agents: A key review.

Huang YM, Alharbi NS, Sun B, Shantharam CS, Rakesh KP, Qin HL.
Eur J Med Chem (2019) 181 : 111566 -111566
PubMed 31401538 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.46	8.46

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1229211	DOLUTEGRAVIR	4.0	1	8.46

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1229211	DOLUTEGRAVIR	EC50	=	3.5	nM	8.46