Assay Detail
Binding
CHEMBL4403232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate preincubated for 1 hr followed by substrate addition by ROS-Glo assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.36 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4568508 | — | — | 1 | 7.07 |
| CHEMBL4515085 | — | — | 1 | 6.99 |
| CHEMBL4457897 | — | — | 1 | 6.96 |
| CHEMBL4460845 | — | — | 1 | 6.84 |
| CHEMBL4444163 | — | — | 1 | 6.82 |
| CHEMBL4468424 | — | — | 1 | 6.76 |
| CHEMBL4441173 | — | — | 1 | 6.75 |
| CHEMBL4467411 | — | — | 1 | 6.74 |
| CHEMBL4545533 | — | — | 1 | 6.72 |
| CHEMBL4441130 | — | — | 1 | 6.63 |
| CHEMBL4441069 | — | — | 1 | 6.63 |
| CHEMBL4462499 | — | — | 1 | 6.59 |
| CHEMBL4442153 | — | — | 1 | 6.59 |
| CHEMBL4457629 | — | — | 1 | 6.55 |
| CHEMBL4565733 | — | — | 1 | 6.55 |
| CHEMBL4550042 | — | — | 1 | 6.52 |
| CHEMBL4586111 | — | — | 1 | 6.51 |
| CHEMBL4447452 | — | — | 1 | 6.47 |
| CHEMBL4470882 | — | — | 1 | 6.46 |
| CHEMBL4574361 | — | — | 1 | 6.43 |
| CHEMBL4564074 | — | — | 1 | 6.42 |
| CHEMBL4540485 | — | — | 1 | 6.41 |
| CHEMBL4450748 | — | — | 1 | 6.40 |
| CHEMBL4457668 | — | — | 1 | 6.37 |
| CHEMBL4463882 | — | — | 1 | 6.37 |
| CHEMBL4466690 | — | — | 1 | 6.26 |
| CHEMBL4456211 | — | — | 1 | 6.22 |
| CHEMBL4551909 | — | — | 1 | 6.19 |
| CHEMBL1618272 | — | — | 1 | 6.18 |
| CHEMBL4552697 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4568508 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4515085 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL4457897 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL4460845 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL4444163 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL4468424 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL4441173 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL4467411 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL4545533 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL4441130 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL4441069 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL4462499 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL4442153 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL4457629 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4565733 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4550042 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL4586111 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4447452 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL4470882 | — | IC50 | = | 343.0 | nM | 6.46 |
| CHEMBL4574361 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4564074 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4540485 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL4450748 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL4457668 | — | IC50 | = | 423.0 | nM | 6.37 |
| CHEMBL4463882 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL4466690 | — | IC50 | = | 554.0 | nM | 6.26 |
| CHEMBL4456211 | — | IC50 | = | 606.0 | nM | 6.22 |
| CHEMBL4551909 | — | IC50 | = | 652.0 | nM | 6.19 |
| CHEMBL1618272 | — | IC50 | = | 665.0 | nM | 6.18 |
| CHEMBL4552697 | — | IC50 | = | 671.0 | nM | 6.17 |
| CHEMBL4528500 | — | IC50 | = | 686.0 | nM | 6.16 |
| CHEMBL4443558 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4456682 | — | IC50 | = | 828.0 | nM | 6.08 |
| CHEMBL4475714 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL4559508 | — | IC50 | = | 1596.0 | nM | 5.80 |
| CHEMBL4463323 | — | IC50 | = | 2164.0 | nM | 5.67 |
| CHEMBL4565942 | — | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL4460658 | — | IC50 | = | 68260.0 | nM | 4.17 |