Assay Detail
Binding
CHEMBL4403240
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Inhibition of recombinant human MAOB expressed in baculovirus infected BTI insect cells using luminogenic MAO substrate measured after 1 hr by MAO-glo assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.56 | 4.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4515085 | — | — | 1 | 4.79 |
| CHEMBL4564074 | — | — | 1 | 4.33 |
| CHEMBL4457629 | — | — | 1 | - |
| CHEMBL4568508 | — | — | 1 | - |
| CHEMBL4457897 | — | — | 1 | - |
| CHEMBL4444163 | — | — | 1 | - |
| CHEMBL4460845 | — | — | 1 | - |
| CHEMBL4550042 | — | — | 1 | - |
| CHEMBL4574361 | — | — | 1 | - |
| CHEMBL4463882 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4515085 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL4564074 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL4457629 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4568508 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4457897 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4444163 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4460845 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4550042 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4574361 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4463882 | — | IC50 | > | 100000.0 | nM | - |