Assay Detail
Binding
CHEMBL4403243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in CHOK1 cells by Qpatch electrophysiological assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.61 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4515085 | — | — | 1 | 5.50 |
| CHEMBL4568508 | — | — | 1 | 5.00 |
| CHEMBL4463882 | — | — | 1 | 4.54 |
| CHEMBL4564074 | — | — | 1 | 4.44 |
| CHEMBL4444163 | — | — | 1 | 4.33 |
| CHEMBL4457629 | — | — | 1 | 4.29 |
| CHEMBL4460845 | — | — | 1 | 4.18 |
| CHEMBL4457897 | — | — | 1 | - |
| CHEMBL4550042 | — | — | 1 | - |
| CHEMBL4574361 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4515085 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4568508 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4463882 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4564074 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4444163 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL4457629 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL4460845 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL4457897 | — | IC50 | - | — | - | |
| CHEMBL4550042 | — | IC50 | - | — | - | |
| CHEMBL4574361 | — | IC50 | - | — | - |