Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4403392

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiparasitic activity against Plasmodium falciparum D6
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

New dimensions in the field of antimalarial research against malaria resurgence.
Narula AK, Azad CS, Nainwal LM.
Eur J Med Chem (2019) 181 : 111353 -111353
PubMed 31525705 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 8.86 10.30
EC50 2 8.70 8.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4483377 1 10.30
CHEMBL4580370 1 10.30
CHEMBL2431810 1 8.89
CHEMBL3264174 1 8.87
CHEMBL3264178 1 8.87
CHEMBL3264179 1 8.87
CHEMBL3264190 1 8.87
CHEMBL3264188 1 8.87
CHEMBL3264503 1 8.58
CHEMBL3361390 1 8.50
CHEMBL3264501 1 8.35
CHEMBL172 (S,R)-MEFLOQUINE 1 7.82
CHEMBL76 CHLOROQUINE 4.0 1 7.79
CHEMBL197308 FERRUGINOL 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4483377 IC50 = 0.05 nM 10.30
CHEMBL4580370 IC50 = 0.05 nM 10.30
CHEMBL2431810 EC50 = 1.3 nM 8.89
CHEMBL3264174 IC50 = 1.35 nM 8.87
CHEMBL3264178 IC50 = 1.35 nM 8.87
CHEMBL3264179 IC50 = 1.35 nM 8.87
CHEMBL3264190 IC50 = 1.35 nM 8.87
CHEMBL3264188 IC50 = 1.35 nM 8.87
CHEMBL3264503 IC50 = 2.63 nM 8.58
CHEMBL3361390 EC50 = 3.18 nM 8.50
CHEMBL3264501 IC50 = 4.46 nM 8.35
CHEMBL172 (S,R)-MEFLOQUINE IC50 = 15.25 nM 7.82
CHEMBL76 CHLOROQUINE IC50 = 16.11 nM 7.79
CHEMBL197308 FERRUGINOL IC50 = 0.9 ug.mL-1 -