Assay Detail
Binding
CHEMBL4403493
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Inhibition of Plasmodium falciparum DHODH
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dihydroorotate dehydrogenase inhibitors in anti-infective drug research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.04 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1956285 | DSM-265 | 2.0 | 1 | 7.48 |
| CHEMBL1738786 | — | — | 1 | 7.42 |
| CHEMBL475813 | — | — | 1 | 7.33 |
| CHEMBL2012958 | — | — | 1 | 7.30 |
| CHEMBL1784567 | — | — | 1 | 6.89 |
| CHEMBL1234899 | — | — | 1 | 6.66 |
| CHEMBL2012951 | — | — | 1 | 6.66 |
| CHEMBL492529 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1956285 | DSM-265 | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1738786 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL475813 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL2012958 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1784567 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1234899 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2012951 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL492529 | — | IC50 | = | 280.0 | nM | 6.55 |