Assay Detail
Binding
CHEMBL4403597
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Inhibition of AgrC-2 in Staphylococcus aureus RN9372 incubated for 1 hr in presence of AIP agonist by beta-lactamase reporter gene assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship Studies of Small Molecule Modulators of the Staphylococcal Accessory Gene Regulator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.57 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4472175 | — | — | 1 | 6.71 |
| CHEMBL4476090 | — | — | 1 | 6.62 |
| CHEMBL1824149 | — | — | 1 | 5.98 |
| CHEMBL1823955 | — | — | 1 | 5.94 |
| CHEMBL1824148 | — | — | 1 | 5.10 |
| CHEMBL2337547 | — | — | 1 | 4.33 |
| CHEMBL4514439 | — | — | 1 | 4.29 |
| CHEMBL1824150 | — | — | 1 | - |
| CHEMBL1824151 | — | — | 1 | - |
| CHEMBL4472809 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4472175 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL4476090 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL1824149 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL1823955 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL1824148 | — | IC50 | = | 7880.0 | nM | 5.10 |
| CHEMBL2337547 | — | IC50 | = | 47300.0 | nM | 4.33 |
| CHEMBL4514439 | — | IC50 | = | 50700.0 | nM | 4.29 |
| CHEMBL1824150 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1824151 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4472809 | — | IC50 | = | 167000.0 | nM | - |