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Assay Detail

CHEMBL4403598

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of AgrC-1 in Staphylococcus aureus AH1677 incubated for 24 hrs by fluorescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Staphylococcus aureus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Structure-Activity Relationship Studies of Small Molecule Modulators of the Staphylococcal Accessory Gene Regulator.
Horswill AR, Gordon CP.
J Med Chem (2020) 63 : 2705 -2730
PubMed 31658413 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.52 9.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2337547 1 9.59
CHEMBL4579664 1 9.31
CHEMBL4455523 1 8.92
CHEMBL4556162 1 8.82
CHEMBL4584804 1 8.70
CHEMBL4446060 1 8.31
CHEMBL4566585 1 8.30
CHEMBL1823954 1 7.00
CHEMBL4440385 1 6.74
CHEMBL4469416 1 6.47
CHEMBL4451523 1 6.33
CHEMBL4448232 1 6.00
CHEMBL4526243 1 5.41
CHEMBL4455790 1 5.32
CHEMBL4465619 1 -
CHEMBL4543358 1 -
CHEMBL4593818 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2337547 IC50 = 0.257 nM 9.59
CHEMBL4579664 IC50 = 0.485 nM 9.31
CHEMBL4455523 IC50 = 1.2 nM 8.92
CHEMBL4556162 IC50 = 1.5 nM 8.82
CHEMBL4584804 IC50 = 2.01 nM 8.70
CHEMBL4446060 IC50 = 4.88 nM 8.31
CHEMBL4566585 IC50 = 5.05 nM 8.30
CHEMBL1823954 IC50 = 101.0 nM 7.00
CHEMBL4440385 IC50 = 181.0 nM 6.74
CHEMBL4469416 IC50 = 340.0 nM 6.47
CHEMBL4451523 IC50 = 468.0 nM 6.33
CHEMBL4448232 IC50 = 1000.0 nM 6.00
CHEMBL4526243 IC50 = 3935.0 nM 5.41
CHEMBL4455790 IC50 = 4742.0 nM 5.32
CHEMBL4465619 IC50 > 10000.0 nM -
CHEMBL4543358 IC50 > 1000.0 nM -
CHEMBL4593818 IC50 > 10000.0 nM -