Assay Detail
Binding
CHEMBL4403607
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Inhibition of AgrC-1 Staphylococcus aureus RN10829 incubated for 45 mins by beta-lactamase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship Studies of Small Molecule Modulators of the Staphylococcal Accessory Gene Regulator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.40 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4527510 | — | — | 1 | 9.51 |
| CHEMBL3289785 | — | — | 1 | 7.92 |
| CHEMBL4476116 | — | — | 1 | 7.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4527510 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL3289785 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4476116 | — | IC50 | = | 16.8 | nM | 7.78 |