Assay Detail
Binding
CHEMBL4403830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human Kv7.3 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium voltage-gated channel subfamily KQT member 3 (CHEMBL2684) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.48 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4457044 | — | — | 1 | 6.04 |
| CHEMBL41355 | EZOGABINE | 4.0 | 1 | 5.41 |
| CHEMBL4545892 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4457044 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL41355 | EZOGABINE | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4545892 | — | EC50 | = | 10500.0 | nM | 4.98 |