Assay Detail
Binding
CHEMBL4403945
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG stably expressed in CHO cells at -90 mV holding potential by electrophysiological assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-<i>a</i>]pyridin-6-yl)amino]-9-(tetrahydro-2<i>H</i>-pyran-4-yl)-7,9-dihydro-8<i>H</i>-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.09 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4474647 | — | — | 1 | 5.09 |
| CHEMBL4439259 | AZD-7648 | 1.0 | 1 | - |
| CHEMBL4513701 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4474647 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4439259 | AZD-7648 | IC50 | > | 198000.0 | nM | - |
| CHEMBL4513701 | — | IC50 | > | 198000.0 | nM | - |