Assay Detail
Binding
CHEMBL4404074
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Inhibition of LasR in Pseudomonas aeruginosa PAO-JP2 harboring plasI-LVAgfp incubated for 6 hrs by fluorescence method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Transcriptional activator protein LasR (CHEMBL1075207) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
Publication
Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.90 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1818523 | — | — | 1 | 5.60 |
| CHEMBL468624 | — | — | 1 | 5.52 |
| CHEMBL1823942 | — | — | 1 | 5.28 |
| CHEMBL463321 | — | — | 1 | 5.26 |
| CHEMBL4549418 | — | — | 1 | 5.01 |
| CHEMBL264944 | — | — | 1 | 4.92 |
| CHEMBL1615001 | — | — | 1 | 4.68 |
| CHEMBL458201 | — | — | 1 | 4.40 |
| CHEMBL1823945 | — | — | 1 | 4.16 |
| CHEMBL473592 | — | — | 1 | 4.14 |
| CHEMBL2229607 | N-CYCLOPENTYLDECANAMIDE | — | 1 | - |
| CHEMBL584972 | — | — | 1 | - |
| CHEMBL575294 | — | — | 1 | - |
| CHEMBL448002 | — | — | 1 | - |
| CHEMBL4544667 | — | — | 1 | - |
| CHEMBL4522587 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1818523 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL468624 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1823942 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL463321 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4549418 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL264944 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1615001 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL458201 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1823945 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL473592 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL2229607 | N-CYCLOPENTYLDECANAMIDE | IC50 | > | 50000.0 | nM | - |
| CHEMBL584972 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL575294 | — | IC50 | = | 116000.0 | nM | - |
| CHEMBL448002 | — | IC50 | = | 175000.0 | nM | - |
| CHEMBL4544667 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4522587 | — | IC50 | > | 100000.0 | nM | - |