Assay Detail
Binding
CHEMBL4404075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of LasR in Pseudomonas aeruginosa PAO-JP2 harboring plasI-LVAgfp incubated for 6 hrs by fluorescence method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Transcriptional activator protein LasR (CHEMBL1075207) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
Publication
Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.95 | 7.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4461584 | — | — | 1 | 7.15 |
| CHEMBL8483 | — | — | 1 | 6.86 |
| CHEMBL4462112 | — | — | 1 | 5.58 |
| CHEMBL4450449 | — | — | 1 | 5.38 |
| CHEMBL4444462 | — | — | 1 | 4.77 |
| CHEMBL468624 | — | — | 1 | - |
| CHEMBL463321 | — | — | 1 | - |
| CHEMBL264944 | — | — | 1 | - |
| CHEMBL4522587 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4461584 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL8483 | — | EC50 | = | 139.0 | nM | 6.86 |
| CHEMBL4462112 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4450449 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4444462 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL468624 | — | EC50 | = | 140000.0 | nM | - |
| CHEMBL463321 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL264944 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL4522587 | — | EC50 | > | 200000.0 | nM | - |