Assay Detail
Binding
CHEMBL4404076
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Inhibition of LasR in Escherichia coli JLD271 harboring pSC11/pJN105L using CPRG as substrate incubated for 4 hrs by Miller assay method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.72 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463321 | — | — | 1 | 7.11 |
| CHEMBL264944 | — | — | 1 | 6.80 |
| CHEMBL1615001 | — | — | 1 | 6.31 |
| CHEMBL448002 | — | — | 1 | 6.00 |
| CHEMBL1823942 | — | — | 1 | 5.64 |
| CHEMBL584972 | — | — | 1 | 5.55 |
| CHEMBL473592 | — | — | 1 | 5.55 |
| CHEMBL575294 | — | — | 1 | 5.46 |
| CHEMBL4544667 | — | — | 1 | 5.33 |
| CHEMBL458201 | — | — | 1 | 4.98 |
| CHEMBL1823945 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463321 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL264944 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1615001 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL448002 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1823942 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL584972 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL473592 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL575294 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4544667 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL458201 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL1823945 | — | IC50 | = | 70000.0 | nM | 4.16 |