Assay Detail
Binding
CHEMBL4404077
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Activation of LasR in Escherichia coli JLD271 harboring pSC11/pJN105L using CPRG as substrate incubated for 4 hrs by Miller assay method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.66 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8483 | — | — | 1 | 8.74 |
| CHEMBL4461584 | — | — | 1 | 8.11 |
| CHEMBL4450449 | — | — | 1 | 7.89 |
| CHEMBL4462112 | — | — | 1 | 7.77 |
| CHEMBL4444462 | — | — | 1 | 7.02 |
| CHEMBL4522587 | — | — | 1 | 6.62 |
| CHEMBL468624 | — | — | 1 | 6.19 |
| CHEMBL4549418 | — | — | 1 | 6.04 |
| CHEMBL463321 | — | — | 1 | 5.35 |
| CHEMBL264944 | — | — | 1 | 5.08 |
| CHEMBL1615001 | — | — | 1 | 4.48 |
| CHEMBL458201 | — | — | 1 | - |
| CHEMBL4544667 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8483 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4461584 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4450449 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4462112 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4444462 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4522587 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL468624 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4549418 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL463321 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL264944 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1615001 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL458201 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4544667 | — | EC50 | > | 100000.0 | nM | - |