Assay Detail
Binding
CHEMBL4404229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SERCA2b expressed in COS7 cells microsomal membranes preincubated for 10 mins followed by addition of ATP and measured after 40 mins by ELISA method
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (CHEMBL3901) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Sarco/Endoplasmic Reticulum Calcium ATPase Inhibitors: Beyond Anticancer Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.48 | 7.05 |
| Ki | 1 | 4.28 | 4.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL468766 | — | — | 1 | 7.05 |
| CHEMBL4534285 | — | — | 1 | 6.68 |
| CHEMBL480626 | — | — | 1 | 5.70 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL468766 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4534285 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL480626 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL140 | CURCUMIN | Ki | = | 53000.0 | nM | 4.28 |