Assay Detail
Binding
CHEMBL4404231
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Inhibition of porcine cerebellar microsomes SERCA2b incubated for 10 mins by enzyme-coupled method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa domesticus |
| Tissue | Cerebellum |
| Subcellular | Microsomes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Sarco/Endoplasmic Reticulum Calcium ATPase Inhibitors: Beyond Anticancer Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.10 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1208858 | CALMIDAZOLIUM CHLORIDE | — | 1 | 6.30 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 4.64 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1208858 | CALMIDAZOLIUM CHLORIDE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL422 | TRIFLUOPERAZINE | IC50 | = | 45000.0 | nM | 4.35 |