Assay Detail
Binding
CHEMBL4404232
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Inhibition of rabbit skeletal muscle microsomes SERCA1a preincubated for 10 mins followed by addition of ATP and measured after 40 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (CHEMBL4693) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Sarco/Endoplasmic Reticulum Calcium ATPase Inhibitors: Beyond Anticancer Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.11 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210411 | — | — | 1 | 5.22 |
| CHEMBL309490 | GALANGIN | — | 1 | 5.05 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210411 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL309490 | GALANGIN | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL50 | QUERCETIN | IC50 | = | 9000.0 | nM | 5.05 |