Assay Detail
Binding
CHEMBL4404236
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rabbit skeletal muscle microsomes SERCA1a by enzyme-coupled method
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (CHEMBL4693) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Sarco/Endoplasmic Reticulum Calcium ATPase Inhibitors: Beyond Anticancer Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.34 | 6.30 |
| Ki | 1 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184450 | — | — | 1 | 6.30 |
| CHEMBL4467779 | — | — | 1 | 6.00 |
| CHEMBL418971 | BISPHENOL A | — | 1 | 5.70 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.52 |
| CHEMBL410063 | PAXILLINE | — | 1 | 5.30 |
| CHEMBL560141 | — | — | 1 | 4.64 |
| CHEMBL2059712 | ALISOL B | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184450 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4467779 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL418971 | BISPHENOL A | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL140 | CURCUMIN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL410063 | PAXILLINE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL560141 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL2059712 | ALISOL B | IC50 | = | 27000.0 | nM | 4.57 |