Assay Detail
Binding
CHEMBL4404242
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rabbit skeletal muscle microsomes SERCA1a incubated for 10 mins by enzyme-coupled method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (CHEMBL4693) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Sarco/Endoplasmic Reticulum Calcium ATPase Inhibitors: Beyond Anticancer Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.21 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1208858 | CALMIDAZOLIUM CHLORIDE | — | 1 | 6.30 |
| CHEMBL13045 | CHELERYTHRINE | — | 1 | 5.92 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 1 | 4.82 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 4.64 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1208858 | CALMIDAZOLIUM CHLORIDE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL13045 | CHELERYTHRINE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL422 | TRIFLUOPERAZINE | IC50 | = | 45000.0 | nM | 4.35 |