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Assay Detail

CHEMBL4404492

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Binding
Inhibition of Enterovirus A71 protease 3C using DabcylKEALFQ-GPPQF-E(Edans)-NH2 as substrate incubated for 10 mins by fluorospectrometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Enterovirus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment.
Zhang L, Lin D, Kusov Y, Nian Y, Ma Q, Wang J, von Brunn A, Leyssen P, Lanko K, Neyts J, de Wilde A, Snijder EJ, Liu H, Hilgenfeld R.
J Med Chem (2020) 63 : 4562 -4578
PubMed 32045235 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.31 5.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3780681 1 5.91
CHEMBL4441971 1 5.77
CHEMBL4572853 1 5.63
CHEMBL4465975 1 5.49
CHEMBL4438019 1 5.33
CHEMBL4474046 1 5.07
CHEMBL4542462 1 4.97
CHEMBL4590737 1 4.86
CHEMBL4442435 1 4.73
CHEMBL4440583 1 -
CHEMBL4435454 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3780681 IC50 = 1220.0 nM 5.91
CHEMBL4441971 IC50 = 1690.0 nM 5.77
CHEMBL4572853 IC50 = 2320.0 nM 5.63
CHEMBL4465975 IC50 = 3240.0 nM 5.49
CHEMBL4438019 IC50 = 4730.0 nM 5.33
CHEMBL4474046 IC50 = 8500.0 nM 5.07
CHEMBL4542462 IC50 = 10810.0 nM 4.97
CHEMBL4590737 IC50 = 13800.0 nM 4.86
CHEMBL4442435 IC50 = 18470.0 nM 4.73
CHEMBL4440583 IC50 > 50000.0 nM -
CHEMBL4435454 IC50 > 30000.0 nM -