Assay Detail
Binding
CHEMBL4404493
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Corona virus B3 protease 3C using DabcylKEALFQ-GPPQF-E(Edans)-NH2 as substrate incubated for 10 mins by fluorospectrometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Coronavirus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.32 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441971 | — | — | 1 | 6.02 |
| CHEMBL4438019 | — | — | 1 | 5.71 |
| CHEMBL4590737 | — | — | 1 | 5.42 |
| CHEMBL4442435 | — | — | 1 | 5.37 |
| CHEMBL4542462 | — | — | 1 | 5.32 |
| CHEMBL4465975 | — | — | 1 | 5.28 |
| CHEMBL3780681 | — | — | 1 | 5.18 |
| CHEMBL4572853 | — | — | 1 | 5.06 |
| CHEMBL4474046 | — | — | 1 | 5.05 |
| CHEMBL4435454 | — | — | 1 | 4.81 |
| CHEMBL4440583 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441971 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4438019 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL4590737 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL4442435 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL4542462 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL4465975 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3780681 | — | IC50 | = | 6560.0 | nM | 5.18 |
| CHEMBL4572853 | — | IC50 | = | 8690.0 | nM | 5.06 |
| CHEMBL4474046 | — | IC50 | = | 8930.0 | nM | 5.05 |
| CHEMBL4435454 | — | IC50 | = | 15380.0 | nM | 4.81 |
| CHEMBL4440583 | — | IC50 | > | 50000.0 | nM | - |