Assay Detail
Functional
CHEMBL4404497
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Antiviral activity against Coronavirus B3 infected in HuH7 cells expressing T7 RNA polymerase assessed as reduction in viral RNA replication incubated for 24 hrs by luciferase reporter gene assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Coronavirus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.28 | 5.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441971 | — | — | 1 | 5.63 |
| CHEMBL4542462 | — | — | 1 | 5.37 |
| CHEMBL3780681 | — | — | 1 | 5.35 |
| CHEMBL4438019 | — | — | 1 | 5.29 |
| CHEMBL4442435 | — | — | 1 | 4.75 |
| CHEMBL4440583 | — | — | 1 | - |
| CHEMBL4572853 | — | — | 1 | - |
| CHEMBL4590737 | — | — | 1 | - |
| CHEMBL4465975 | — | — | 1 | - |
| CHEMBL4474046 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441971 | — | EC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL4542462 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3780681 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4438019 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4442435 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4440583 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4572853 | — | EC50 | - | — | - | |
| CHEMBL4590737 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4465975 | — | EC50 | - | — | - | |
| CHEMBL4474046 | — | EC50 | - | — | - |