Assay Detail
Functional
CHEMBL4404498
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS coronavirus infected in HuH7 cells expressing T7 RNA polymerase assessed as reduction in viral RNA replication incubated for 24 hrs by luciferase reporter gene assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV (CHEMBL4303836) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.50 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441971 | — | — | 1 | 5.85 |
| CHEMBL4442435 | — | — | 1 | 5.72 |
| CHEMBL3780681 | — | — | 1 | 5.70 |
| CHEMBL4438019 | — | — | 1 | 5.44 |
| CHEMBL4542462 | — | — | 1 | 5.17 |
| CHEMBL4590737 | — | — | 1 | 5.14 |
| CHEMBL4440583 | — | — | 1 | - |
| CHEMBL4572853 | — | — | 1 | - |
| CHEMBL4465975 | — | — | 1 | - |
| CHEMBL4474046 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441971 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4442435 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3780681 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4438019 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4542462 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4590737 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4440583 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL4572853 | — | EC50 | - | — | - | |
| CHEMBL4465975 | — | EC50 | - | — | - | |
| CHEMBL4474046 | — | EC50 | > | 20000.0 | nM | - |