Assay Detail
Functional
CHEMBL4404505
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Antiviral activity against Enterovirus D68 infected in HeLa Rh cells assessed as reduction in virus-induced cytopathic effect incubated for 3 days by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | enterovirus D68 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.00 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3780681 | — | — | 1 | 6.32 |
| CHEMBL4441971 | — | — | 1 | 6.32 |
| CHEMBL4590737 | — | — | 1 | 5.35 |
| CHEMBL4442435 | — | — | 1 | - |
| CHEMBL4542462 | — | — | 1 | - |
| CHEMBL4438019 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3780681 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4441971 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4590737 | — | EC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL4442435 | — | EC50 | - | — | - | |
| CHEMBL4542462 | — | EC50 | - | — | - | |
| CHEMBL4438019 | — | EC50 | - | — | - |