Assay Detail
Functional
CHEMBL4404575
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Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells incubated for 1 hr and measured after 36 hrs by PR8-PB2 Gaussia luciferase reporter gene assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.47 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435674 | — | — | 1 | 7.14 |
| CHEMBL4453880 | — | — | 1 | 6.95 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 6.74 |
| CHEMBL4438284 | — | — | 1 | 6.71 |
| CHEMBL4577797 | — | — | 1 | 6.68 |
| CHEMBL4450131 | — | — | 1 | 6.58 |
| CHEMBL4438419 | — | — | 1 | 6.57 |
| CHEMBL4461234 | — | — | 1 | 6.49 |
| CHEMBL4558751 | — | — | 1 | 6.42 |
| CHEMBL4559323 | — | — | 1 | 6.30 |
| CHEMBL4450727 | — | — | 1 | 6.23 |
| CHEMBL4443146 | — | — | 1 | 6.14 |
| CHEMBL4590714 | — | — | 1 | 6.07 |
| CHEMBL4527195 | — | — | 1 | 6.05 |
| CHEMBL4450397 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435674 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4453880 | — | EC50 | = | 113.0 | nM | 6.95 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | = | 181.0 | nM | 6.74 |
| CHEMBL4438284 | — | EC50 | = | 195.0 | nM | 6.71 |
| CHEMBL4577797 | — | EC50 | = | 211.0 | nM | 6.68 |
| CHEMBL4450131 | — | EC50 | = | 263.0 | nM | 6.58 |
| CHEMBL4438419 | — | EC50 | = | 272.0 | nM | 6.57 |
| CHEMBL4461234 | — | EC50 | = | 324.0 | nM | 6.49 |
| CHEMBL4558751 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4559323 | — | EC50 | = | 505.0 | nM | 6.30 |
| CHEMBL4450727 | — | EC50 | = | 587.0 | nM | 6.23 |
| CHEMBL4443146 | — | EC50 | = | 724.0 | nM | 6.14 |
| CHEMBL4590714 | — | EC50 | = | 852.0 | nM | 6.07 |
| CHEMBL4527195 | — | EC50 | = | 885.0 | nM | 6.05 |
| CHEMBL4450397 | — | EC50 | = | 989.0 | nM | 6.00 |